Casein phosphopeptides and calcium absorption
Casein phosphopeptides (CPPs) are components of milk casein. CPPs are believed to exert a positive influence on calcium absorption since studies have shown a high capacity of CPPs to form soluble complexes with calcium1,2.
Calcium is a nutrient needed for normal growth and bone development in children 3. In the European Union there are several authorised health claims for calcium 4 as follows:
- “Calcium is needed for normal growth and development of bone in children”
- “Calcium is needed for the maintenance of normal bones”
Based on in vitro and in vivo studies it may be suggested that CPPs exert a function in calcium absorption5-8 and calcium availability in bones7-8 and reduced bone degradation9.
Lacprodan® DI-2021 is a hydrolysate containing at least 22% CPP. This high CPP concentration allows for potentially improving calcium bioavailability.
CPP nutrient fortifier status in China
As a nutrient fortifier, CPP is regulated by the Chinese food safety standard GB 14880-2012, which allows a maximum dosage of 0,3% in products for children up to three years of age.
References:
1. Fitzgerald & Meisel 2003.
2. Hansen et al. 1997. J Pediatr Gastroenterol Nutr. 24; 56-62)
3. Commission Regulation (EU) 983/2009 of 21 October 2009
4. Commission Regulation (EU) 432/2012 of 16/05/2012
5. Tulipano et al. 2010. Regulatory Peptides. 160; 168-174
6. Donida et al. 2009. Peptides. 30; 2233-224
7. Mora-Gutierrez et al. 2007. J Dairy Res. 74 ; 356-366
8. Tsuchita et al. 2001. Br J Nutr. 85; 5-10
9. Liu et al. 2017. Food Funct. 8; 4487-4495
